Mechanism of physiological and pathological angiogenesis
Translational regulation of gene expression in endothelial cells
Angiogenesis is a process of making new blood vessels from pre-existing vasculature. This phenomenon is executed by endothelial cells and triggered by growth factors (e.g. VEGFA). Abnormal angiogenesis is a hallmark of several pathological conditions including retinopathies and cancer. We are interested in the molecular events that lead to such pathological angiogenesis. Specifically we are investigating the contribution of translational control of gene expression to angiogenesis regulation.