Sandeep M. Eswarappa

Assistant Professor

MBBS

Mysore Medical College (1997 to 2003)

Ph.D.

Indian Institute of Science (2003 to 2008)

Postdoctoral Research

Cleveland Clinic, USA (2009 to 2015)
Tel: +91 80 22932881
Email: sandeep@biochem.iisc.ernet.in, sandeep.kadur@gmail.com








 Research

  • Mechanism of physiological and pathological angiogenesis
  • Translational regulation of gene expression in endothelial cells

Angiogenesis is a process of making new blood vessels from pre-existing vasculature. This phenomenon is executed by endothelial cells and triggered by growth factors (e.g. VEGFA). Abnormal angiogenesis is a hallmark of several pathological conditions including retinopathies and cancer. We are interested in the molecular events that lead to such pathological angiogenesis. Specifically we are investigating the contribution of translational control of gene expression to angiogenesis regulation.


 Key Publications

  • Eswarappa SM and Fox PL (2015) Antiangiogenic VEGF-Ax: A New Participant in Tumor Angiogenesis. Cancer Res (in press)

  • Eswarappa SM, Potdar AA, Koch WJ, et al. (2014) Programmed translational readthrough of VEGFA mRNA generates anti-angiogenic VEGF-Ax. Cell 157:1605-1618. [Featured in Faculty of 1000 and highlighted in Nature Review Cancer]

  • Fan Y, Potdar AA, Gong Y, Eswarappa SM, et al., (2014) Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation. Nat Cell Biol 16:445-456.

  • Eswarappa SM and Fox PL (2013) Citric acid cycle and the origin of MARS. Trends Biochem Sci 38: 222-228.

  • Fan Y, Eswarappa SM, Hitomi M, Fox PL (2012) Myo1c facilitates G-actin transport to the leading edge of migrating endothelial cells. J Cell Biol 198: 47-55. [Featured in Faculty of 1000]

  • Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, et al (2012) Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol 14: 1046-1056. [Featured in Faculty of 1000]



 Collaborators

  • Dr. Paul L. Fox
    Cleveland Clinic Lerner Research Institute,
    Cleveland, USA
  • Dr. Belinda Willard
    Cleveland Clinic Lerner Research Institute,
    Cleveland, USA