R .Manjunath

Associate Professor

Ph.D.

Indian Institute of Science, Bangalore, India. 1981

Postdoctoral Research

National Institutes of Health, U.S.A.
Dartmouth Medical School, U.S.A. 1981-1987
Tel: +91-80-2293 2309
Email: mjnhm@biochem.iisc.ernet.in


 Research

  • Viral Immunology

Research and development activity in the laboratory has centered on immune responses against viruses, specifically Japanese encephalitis virus. The efficiency of virus clearance from peripheral organs is determined to a large extent on the expression of MHC antigens. Although Cytotoxic T Lymphocytes (CTL) are associated with viral elimination in many infectious conditions, elimination of neurotropic viruses from the Central Nervous System (CNS) is more complex due to the lowered expression of MHC antigens on neuronal cells. The successful elimination of neurotropic infections depends on a delicate balance between immune responses that eliminate the virus and those that lead to CNS inflammation due to CTL lysis of neurons. Hence the mechanisms with which an ultimate balance between cell mediated and humoral immune responses against JEV is established are being persued in this laboratory.

Ongoing research in the laboratory has focussed on demonstrating the role of CTL in JEV infection of mice. The nature of JEV epitopes recognised by JEV specific CTL, the manner of JEV antigen presentation by peripheral and CNS antigen presenting cells and the mechanism of antigen clearance from the CNS in mice is being investigated.

 Lab Members


 Key Publications

  • Murali Krishna, K., Ravi, V. and Manjunath, R., 1995. Japanese encephalitis virus infection of mouse cell lines: Ability to prime mice for the generation of virus-specific Cytotoxic T Lymphocytes and differences in CTL recognisable viral determinants. Arch. Virol. 140, 127-143.
  • Murali Krishna, K., Ramireddy, B., Ravi, V. and Manjunath, R., 1995. Recognition of Nonstrctural protein peptides by Cytotoxic T Lymphocytes raised against Japanese encephalitis virus. Microbiol. Immunol. 39, 1021-1024.
  • Murali Krishna, K., Ravi, V. and Manjunath, R., 1996. Protection of Adult but not Newborn mice against intracerebral lethal challenge with Japanese encephalitis virus by adoptively transferred virus-specific Cytotoxic T Lymphocytes: Requirement for L3T4+ cells. J. Gen. Virol. 77, 705-714.
  • Desai, A., Murali Krishna, K, Ramireddy, B., Ravi, V and Manjunath, R., 1997. In vivo clearance of Japanese encephalitis virus by adoptively transferred virus specific Cytotoxic T lymphocytes. J. Biosciences 22, 33-45.